Ordinary Shares, par value NIS 0.0000769 per share

Entera Bio Ltd.

KIRYAT HADASSAH, MINRAV BUILDING, JERUSALEM, L3, 9112002

This statement is filed by: (i) Biotechnology Value Fund, L.P., a Delaware limited partnership ("BVF"); (ii) BVF I GP LLC, a Delaware limited liability company ("BVF GP"), which serves as general partner of BVF; (iii) Biotechnology Value Fund II, L.P., a Delaware limited partnership ("BVF2"); (iv) BVF II GP LLC, a Delaware limited liability company ("BVF2 GP"), which serves as general partner of BVF2; (v) Biotechnology Value Trading Fund OS LP, a Cayman Islands limited partnership ("Trading Fund OS"); (vi) BVF Partners OS Ltd., a Cayman Islands limited liability company ("Partners OS"), which serves as general partner of Trading Fund OS; (vii) BVF GP Holdings LLC, a Delaware limited liability company ("BVF GPH"), which is the sole member of each of BVF GP and BVF2 GP; (viii) BVF Partners L.P., a Delaware limited partnership ("Partners"), which serves as the investment manager of each of BVF, BVF2, Trading Fund OS and a certain managed account (the "Partners Managed Account"), and as the sole member of Partners OS; (ix) BVF Inc., a Delaware corporation, which serves as general partner of Partners and the managing member of BVF GPH; and (x) Mark N. Lampert, who serves as the sole officer and director of BVF Inc. Each of the foregoing is referred to as a "Reporting Person" and collectively as the "Reporting Persons." Each of the Reporting Persons is party to that certain Joint Filing Agreement, as further described in Item 6. Accordingly, the Reporting Persons are hereby filing a joint Schedule 13D.

The business address of BVF, BVF GP, BVF2, BVF2 GP, BVF GPH, Partners, BVF Inc. and Mr. Lampert is 44 Montgomery St., 40th Floor, San Francisco, California 94104. The business address of Trading Fund OS and Partners OS is PO Box 309 Ugland House, Grand Cayman, KY1-1104, Cayman Islands.

The principal business of each of BVF, BVF2 and Trading Fund OS is investing in securities. The principal business of BVF GP, BVF2 GP and Partners OS is serving as the general partner of BVF, BVF2 and Trading Fund OS, respectively. The principal business of BVF GPH is serving as the sole member of each of BVF GP and BVF2 GP. The principal business of Partners is serving as the investment manager of each of BVF, BVF2, Trading Fund OS and the Partners Managed Account, and as the sole member of Partners OS. The principal business of BVF Inc. is serving as the general partner of Partners and as the managing member of BVF GPH. Mr. Lampert is the sole officer and director of BVF Inc.

No Reporting Person has, during the last five years, been party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

Mr. Lampert is a citizen of the United States of America.

The aggregate percentage of Shares reported owned by each person named herein is based upon a denominator that is the sum of: (i) 49,290,196 Shares outstanding as of July 26, 2026, as set forth in the July Securities Purchase Agreement, (ii) 122,961,215 Shares issued in the July Private Placement, as reported in the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on July 28, 2026, and (iii) 172,228 Shares underlying certain July Pre-Funded Warrants held by certain of the Reporting Persons that are currently exercisable, as applicable. As of the close of business on August 4, 2026, the Reporting Persons and the Partners Managed Account held 5,402,789 April Pre-Funded Warrants exercisable for an aggregate of 5,402,789 Shares. The April Pre-Funded Warrants are immediately exercisable and may be exercised at any time, have no expiration date, and have an exercise price of NIS 0.0000769 per Share. The April Pre-Funded Warrants may not be exercised if the aggregate number of Shares beneficially owned by the holder thereof, together with its affiliates, would exceed 4.99% of the Shares outstanding immediately after exercise thereof (the "April Pre-Funded Warrants Blocker"). As of the close of business on August 4, 2026, the April Pre-Funded Warrants Blocker prohibited the exercise of all the April Pre-Funded Warrants held by the Reporting Persons and the Partners Managed Account. As of the close of business on August 4, 2026, the Reporting Persons and the Partners Managed Account held Warrants exercisable for an aggregate of 11,741,683 Shares. Each Warrant has an exercise price of $1.24 per Share, becomes exercisable six months following the April Closing Date, and expires five years from the April Closing Date. The Warrants may not be exercised if the aggregate number of Shares beneficially owned by the holder thereof, together with its affiliates, would exceed 4.99% of the Shares outstanding immediately after exercise thereof (the "Warrants Blocker"). As of the close of business on August 4, 2026, the Warrants Blocker prohibited the exercise of all the Warrants held by the Reporting Persons and the Partners Managed Account. As of the close of business on August 4, 2026, the Reporting Persons and the Partners Managed Account held 11,842,695 July Pre-Funded Warrants exercisable for an aggregate of 11,842,695 Shares. The July Pre-Funded Warrants are immediately exercisable and may be exercised at any time, have no expiration date, and have an exercise price of NIS 0.0000769 per Share. The July Pre-Funded Warrants may not be exercised if the aggregate number of Shares beneficially owned by the holder thereof, together with its affiliates, would exceed 9.99% of the Shares outstanding immediately after exercise thereof (the "July Pre-Funded Warrants Blocker"). As of the close of business on August 4, 2026, the July Pre-Funded Warrants Blocker limited the exercise of the July Pre-Funded Warrants held by the Reporting Persons and the Partners Managed Account to 172,228 Shares out of the 11,842,695 Shares underlying the July Pre-Funded Warrants held by them. As of the close of business on August 4, 2026, (i) BVF beneficially owned 9,171,741 Shares, including 172,228 Shares underlying certain July Pre-Funded Warrants held by it, and excluding (a) 2,807,485 Shares underlying the April Pre-Funded Warrants held by it, (b) 6,093,561 Shares underlying certain July Pre-Funded Warrants held by it and (c) 6,101,406 Shares underlying the Warrants held by it, representing percentage ownership of approximately 5.3% of the Shares outstanding, (ii) BVF2 beneficially owned 6,685,480 Shares, excluding (a) 2,145,437 Shares underlying the April Pre-Funded Warrants held by it, (b) 4,632,931 Shares underlying the July Pre-Funded Warrants held by it and (c) 4,662,600 Shares underlying the Warrants held by it, representing percentage ownership of approximately 3.9% of the Shares outstanding, and (iii) Trading Fund OS beneficially owned 1,124,329 Shares, excluding (a) 361,603 Shares underlying the April Pre-Funded Warrants held by it, (b) 778,854 Shares underlying the July Pre-Funded Warrants held by it and (c) 785,857 Shares underlying the Warrants held by it, representing percentage ownership of less than 1% of the Shares outstanding. BVF GP, as the general partner of BVF, may be deemed to beneficially own the 9,171,741 Shares beneficially owned by BVF, representing percentage ownership of approximately 5.3% of the Shares outstanding. BVF2 GP, as the general partner of BVF2, may be deemed to beneficially own the 6,685,480 Shares beneficially owned by BVF2, representing percentage ownership of approximately 3.9% of the Shares outstanding. Partners OS, as the general partner of Trading Fund OS, may be deemed to beneficially own the 1,124,329 Shares beneficially owned by Trading Fund OS, representing percentage ownership of less than 1% of the Shares outstanding. BVF GPH, as the sole member of each of BVF GP and BVF2 GP, may be deemed to beneficially own the 15,857,221 Shares beneficially owned in the aggregate by BVF and BVF2, representing percentage ownership of approximately 9.2% of the Shares outstanding. Partners, as the investment manager of BVF, BVF2, Trading Fund OS and the Partners Managed Account and the sole member of Partners OS, may be deemed to beneficially own the 17,225,121 Shares beneficially owned in the aggregate by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account, representing percentage ownership of approximately 9.99% of the Shares outstanding, which includes 243,571 Shares held in the Partners Managed Account, which excludes (a) 88,264 Shares underlying the April Pre-Funded Warrants held in the Partners Managed Account, (b) 165,121 Shares underlying the July Pre-Funded Warrants held in the Partners Managed Account and (c) 191,820 Shares underlying the Warrants held in the Partners Managed Account (representing percentage ownership of less than 1% of the Shares outstanding by the Partners Managed Account). BVF Inc., as the general partner of Partners, may be deemed to beneficially own the 17,225,121 Shares beneficially owned by Partners, representing percentage ownership of approximately 9.99% of the Shares outstanding. Mr. Lampert, as the sole director and officer of BVF Inc., may be deemed to beneficially own the 17,225,121 Shares beneficially owned by BVF Inc., representing percentage ownership of approximately 9.99% of the Shares outstanding. The foregoing should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of any Shares owned by another Reporting Person. BVF GP disclaims beneficial ownership of the Shares beneficially owned by BVF. BVF2 GP disclaims beneficial ownership of the Shares beneficially owned by BVF2. Partners OS disclaims beneficial ownership of the Shares beneficially owned by Trading Fund OS. BVF GPH disclaims beneficial ownership of the Shares beneficially owned by BVF and BVF2. Each of Partners, BVF Inc. and Mr. Lampert disclaims beneficial ownership of the Shares beneficially owned by BVF, BVF2 and Trading Fund OS and held in the Partners Managed Account.

Each of BVF, BVF2 and Trading Fund OS shares with Partners voting and dispositive power over the Shares each such entity beneficially owns. BVF shares with BVF GP voting and dispositive power over the Shares beneficially owned by BVF. BVF2 shares with BVF2 GP voting and dispositive power over the Shares beneficially owned by BVF2. Each of BVF GP and BVF2 GP shares with BVF GPH voting and dispositive power over the Shares each such entity beneficially owns. Trading Fund OS shares with Partners OS voting and dispositive power over the Shares beneficially owned by Trading Fund OS. Partners, BVF Inc. and Mr. Lampert share voting and dispositive power over the Shares they may be deemed to beneficially own with BVF, BVF GP, BVF2, BVF2 GP, Trading Fund OS, Partners OS and BVF GPH and held in the Partners Managed Account.

Except as otherwise set forth herein, including in Items 3 and 4 above, none of the Reporting Persons has entered into any transactions in the securities of the Issuer during the past 60 days.

No person other than the Reporting Persons is known to have the right to receive, or the power to direct the receipt of dividends from, or proceeds from the sale of, the Shares.

Not applicable.