13D Filings
Lyra Therapeutics, Inc.
LYRA
Amendment
Ownership

15.55%

Total Shares

255,750

Issuer CIK

1327273

CUSIP

55234L105

Event Date

Aug 11, 2025

Accepted

Aug 14, 2025, 05:21 PM

Reporting Persons (4)
Joint Filing

This is a joint filing. The reported shares may overlap between reporting persons and should not be summed.

NameType% of ClassAggregateSole VotingShared Voting
Perceptive Advisors LLC
Investment Adviser
15.55%255,7500255,750
Joseph Edelman
Individual
15.55%255,7500255,750
Perceptive Life Sciences Master Fund, Ltd.
CO
13.99%229,9820229,982
Perceptive LS (A), LLC
CO
1.57%25,768025,768
Disclosure Items (2)

Security Title

Common Stock, $0.001 par value

Issuer Name

Lyra Therapeutics, Inc.

Issuer Address

480 Arsenal Way, Watertown, MA, 02472

Percentage of Class

The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 1,644,454 outstanding shares of Common Stock as of August 8, 2025 as reported by the Issuer in its Form 10-Q filed with the Securities and Exchange Commission on August 12, 2025.

Number of Shares

The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference.