Common Stock, par value $0.0001 per share

OnKure Therapeutics, Inc.

6707 Winchester Circle, Suite 400, Boulder, CO, 80301

The aggregate number and percentage of the shares of Common Stock outstanding beneficially owned by each Reporting Person set forth below and on the cover pages hereof are based on 12,652,890 shares of Common Stock outstanding as of November 4, 2024, as reported in the Issuer's Form 10-Q filed with the SEC on November 7, 2024.

(i) sole power to vote or to direct the vote: see line 7 of cover sheets; (ii) shared power to vote or to direct the vote: see line 8 of cover sheets; (iii) sole power to dispose or to direct the disposition: see line 9 of cover sheets; (iv) shared power to dispose or to direct the disposition: see line 10 of cover sheets. By virtue of the relationships described herein, the Reporting Persons may be deemed to constitute a "group" for purposes of Section 13(d)(3) of the Act. The filing of this Statement shall not be construed as an admission that the Reporting Persons are a group, or have agreed to act as a group. Each Reporting Person expressly disclaims beneficial ownership of the securities reported herein, except to the extent such Reporting Person actually exercises voting or dispositive power with respect to such securities.

Except as set forth herein, none of the Reporting Persons has effected any transactions in shares of the Issuer's Common Stock during the last 60 days.

No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the shares of Common Stock beneficially owned by any of the Reporting Persons

The Reporting Persons ceased to own more than five percent of the outstanding Common Stock on January 16, 2025.