Common Stock, par value $0.01 per share

OPKO HEALTH, INC.

4400 BISCAYNE BLVD., MIAMI, FL, 33137

Dr. Hsiao may be deemed to beneficially own 35,677,284 shares of Common Stock, which consist of (i) 5,127,404 shares of Common Stock held by Hsu Gamma, and (ii) 30,549,880 shares of Common Stock held individually. The 30,549,880 shares of Common Stock individually held by Dr. Hsiao include (i) 27,999,880 shares of Common Stock held individually; and (ii) options to purchase 2,550,000 shares of Common Stock, exercisable within 60 days of the date hereof. The 35,677,284 shares of Common Stock beneficially owned by Dr. Hsiao constitute approximately 4.48% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person. Dr. Hsiao has sole voting and dispositive power over 35,677,284 shares of Common Stock. Hsu Gamma beneficially owns 5,127,404 shares of Common Stock, which constitutes approximately 0.65% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting person. Dr. Hsiao is the general partner of Hsu Gamma and holds sole voting and dispositive power with respect to the 5,127,404 shares of Common Stock held by Hsu Gamma.

Dr. Hsiao may be deemed to beneficially own 35,677,284 shares of Common Stock, which consist of (i) 5,127,404 shares of Common Stock held by Hsu Gamma, and (ii) 30,549,880 shares of Common Stock held individually. The 30,549,880 shares of Common Stock individually held by Dr. Hsiao include (i) 27,999,880 shares of Common Stock held individually; and (ii) options to purchase 2,550,000 shares of Common Stock, exercisable within 60 days of the date hereof. The 35,677,284 shares of Common Stock beneficially owned by Dr. Hsiao constitute approximately 4.48% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person. Dr. Hsiao has sole voting and dispositive power over 35,677,284 shares of Common Stock. Hsu Gamma beneficially owns 5,127,404 shares of Common Stock, which constitutes approximately 0.65% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting person. Dr. Hsiao is the general partner of Hsu Gamma and holds sole voting and dispositive power with respect to the 5,127,404 shares of Common Stock held by Hsu Gamma.

In the last 60 days prior to the filing of this Amendment No. 11, Hsu Gamma and Dr. Hsiao have not effected any transactions in the shares of Common Stock.

Except as described herein, no other person is known by any Reporting Person to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, any shares of the Issuer beneficially owned by them.

On or about April 2, 2025, Dr. Hsiao ceased to beneficially own more than 5% of the Common Stock.