13D Filings
ENTRADA THERAPEUTICS, INC.
TRDA
Amendment
Ownership

10.80%

Total Shares

4,123,849

Issuer CIK

1689375

CUSIP

29384C108

Event Date

Nov 13, 2025

Accepted

Nov 18, 2025, 04:38 PM

Reporting Persons (7)
Joint Filing

This is a joint filing. The reported shares may overlap between reporting persons and should not be summed.

NameType% of ClassAggregateSole VotingShared Voting
Kush Parmar
Individual
10.80%4,123,84967,4704,056,379
Andrew J. Schwab
Individual
10.60%4,056,37904,056,379
Scott M. Rocklage
Individual
7.80%2,963,06602,963,066
5AM Partners V, LLC
Other
7.80%2,963,06602,963,066
5AM Ventures V, L.P.
Partnership
7.80%2,963,06602,963,066
5AM Opportunities I (GP), LLC
Other
2.90%001,093,313
5AM Opportunities I, L.P.
Partnership
2.90%1,093,31301,093,313
Disclosure Items (3)

Security Title

Common Stock, par value $0.0001 per share

Issuer Name

ENTRADA THERAPEUTICS, INC.

Issuer Address

ONE DESIGN CENTER PLACE, BOSTON, MA, 02210

Percentage of Class

Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D/A set forth the aggregate number of shares of common stock and percentages of the shares of common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon 38,219,232 shares of common stock outstanding as of October 31, 2025 as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 6, 2025. The Reporting Persons' beneficial ownership of the Issuer's common stock consists of (i) 2,963,066 shares of common stock directly held by 5AM V; (ii) 1,093,313 shares of common stock directly held by 5AM Opportunities; and (iii) 67,470 vested stock options (right to buy) held by Dr. Parmar. 5AM Partners V is the sole general partner of 5AM V and shares voting and dispositive power over the securities held by 5AM Partners V. 5AM Opportunities GP is the sole general partner of 5AM Opportunities and shares voting and dispositive power over the securities held by 5AM Opportunities. Schwab and Drs. Parmar and Rocklage are the managing members of 5AM Partners V and share voting and dispositive power over the securities held by 5AM V. Schwab and Dr. Parmar are the managing members of 5AM Opportunities GP and share voting and dispositive power over the securities held by 5AM Opportunities.

Number of Shares

Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D/A set forth the number of shares of common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference.

Transactions

On November 14, 2025, 5AM V sold an aggregate of 200,000 shares in open market transactions at prices ranging from $8.80 to $9.023 (weighted average sales price of $8.80 per share). Except as set forth above, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer during the past sixty days.

Shareholders

No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the securities beneficially owned by any of the Reporting Persons.

Date of 5% Ownership

Not Applicable.

Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit A to the Reporting Persons' Schedule 13D, filed with the SEC on November 12, 2021).